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Description for Protein KHK

ketohexokinase (fructokinase)
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.3
    KEGG - Orthology:
    K00846
    KEGG - Pathway(s):
    hsa00051; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fructokinase, KHK; Ketohexokinase (fructokinase); EC 2.7.1.3; Hepatic fructokinase; Ketohexokinase isoform b; Ketohexokinase isoform a; Hepatic fructokinase deficiency; ketohexokinase deficiency
    Approved Symbol:
    KHK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Fructosuria, essential(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11774 Entrez Gene ID: 3795 OMIM ID: 229800 Swissprot Accession: P50053; Q6IBK2;