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Description for Protein KCNN3

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 1; secretome: 1)
Summary:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04944
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SK3; SKCA3; Small conductance calcium-activated potassium channel protein 3 isoform a; Small conductance calcium-activated potassium channel protein 3 isoform b; KCa2.3; hSK3; Small conductance calcium-activated potassium channel protein 3
    Approved Symbol:
    KCNN3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Miconazole(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 5
    • Additional Identifiers:

    HPRD: 04283 Entrez Gene ID: 3782 OMIM ID: 602983 Swissprot Accession: Q9UGI6; Q8WXG7;