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Description for Protein KCNN2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04943
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SKCA2; SK2; hSK2; KCa2.2; Apamin sensitive small conductance Ca2+ activated potassium channel; Small conductance calcium activated potassium channel protein 2 isoform a; Potassium intermediate/small conductance calcium activated channel subfamily N member 2; Small conductance calcium activated potassium channel protein 2 isoform b
    Approved Symbol:
    KCNN2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Miconazole(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 09323 Entrez Gene ID: 3781 OMIM ID: 605879 Swissprot Accession: Q9H2S1; Q6PJI0;