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Description for Protein KCNMA1

potassium large conductance calcium-activated channel, subfamily M, alpha member 1
8 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04936
    KEGG - Pathway(s):
    hsa04270; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SLO; BKTM; MaxiK; SAKCA; KCa1.1; bA205K10.1; MGC71881; Stretch-activated Kca channel; Maxi K channel; Calcium-activated potassium channel alpha subunit 1; Calcium-activated potassium channel, subfamily M, alpha subunit 1; BK channel; K(VCA)alpha; BKCA alpha; Slowpoke-like; Slo-alpha; Slo1; Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform a; Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b
    Approved Symbol:
    KCNMA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Bendroflumethiazide(db);
  • Chlorzoxazone(db);
  • Cromoglicate(db);
  • Diazoxide(db);
  • Enflurane(db);
  • Halothane(db);
  • Hydrochlorothiazide(db);
  • Hydroflumethiazide(db);
  • Miconazole(db)

    Associated Genetic Diseases:

  • Generalized epilepsy and paroxysmal dyskinesia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 15967 Entrez Gene ID: 3778 OMIM ID: 600150 Swissprot Accession: Q12791; Q59FH2;