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Description for Protein KCNK3

potassium channel, subfamily K, member 3
9 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04914
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    TWIK related acid sensitive K+ channel; TASK; Two pore potassium channel KT3.1; Acid-sensitive potassium channel protein TASK-1; TASK1; Potassium inwardly rectifying channel subfamily K, member 3
    Approved Symbol:
    KCNK3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Doxapram(db);
  • Halothane(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 5
    • Additional Identifiers:

    HPRD: 04451 Entrez Gene ID: 3777 OMIM ID: 603220 Swissprot Accession: Q53SU2; O14649;