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Description for Protein KCNJ8

potassium inwardly-rectifying channel, subfamily J, member 8
5 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05001
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Potassium channel, inwardly rectifying, subfamily J, member 8; Inwardly rectifier K+ channel Kir6.1; uKATP 1; Inwardly rectifying potassium channel Kir6.1; KIR6.1
    Approved Symbol:
    KCNJ8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Gliquidone(db);
  • Glisoxepide(db);
  • Levosimendan(db);
  • Phenformin(db);
  • Thiamylal(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 02962 Entrez Gene ID: 3764 OMIM ID: 600935 Swissprot Accession: Q15842;