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Description for Protein KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • BTB: Broad-Complex, Tramtrack and Bric a brac
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04893
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Potassium voltage gated channel Shal related subfamily member 3; KV4.3; KSHIVB; Potassium ionic channel Kv4.3; Sha1-related potassium channel Kv4.3; Voltage-gated potassium channel Kv4.3; OTTHUMP00000063948; Potassium voltage-gated channel, Shal-related subfamily, member 3 isoform 1; Potassium voltage-gated channel, Shal-related subfamily, member 3 isoform 2
    Approved Symbol:
    KCND3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amitriptyline(db);
  • Disopyramide(db);
  • Imipramine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 16104 Entrez Gene ID: 3752 OMIM ID: 605411 Swissprot Accession: Q9UK17; Q14D71;