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Description for Protein CD82

CD82 molecule
36 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; platelet: 4)
Summary:
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06509
    KEGG - Pathway(s):
    hsa04115
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Leukocyte surface antigen R2; SAR2; Suppressor of tumorigenicity 6; C33 antigen; ST6; R2 leukocyte antigen; Inducible membrane protein R2; 4F9; C33; GR15; IA4; Tetraspanin 27; Tspan 27; Kangai 1; Metastasis suppressor Kangai 1; KAI1 prostate cancer antimetastasis gene KAI1; KAI1; R2; Inducible membrane protein; CD82 antigen isoform 1; CD82 antigen isoform 2
    Approved Symbol:
    CD82
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 3
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 09004 Entrez Gene ID: 3732 OMIM ID: 600623 Swissprot Accession: P27701; Q7Z5N2;