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Description for Protein TRIM23

tripartite motif-containing 23
25 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BBOX: B-Box-type zinc finger
  • BBC: B-Box C-terminal domain
  • RING: Ring finger
  • CC: Coiled Coil
  • ARF: ARF-like small GTPases
  • ARF, ADP-ribosylation factor
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07963
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ARD1; RNF46; ARF domain protein 1; GTP binding protein ARD 1; Tripartite motif protein 23; ADP ribosylation factor domain protein 1 isoform beta; ADP ribosylation factor domain protein 1 isoform gamma; ADP-ribosylation factor domain protein 1 isoform alpha
    Approved Symbol:
    TRIM23
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03449 Entrez Gene ID: 373 OMIM ID: 601747 Swissprot Accession: P36406;