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Description for Protein JAK2

Janus kinase 2
93 total interacting proteins; 55 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.10.2
KEGG - Orthology:
K04447
KEGG - Pathway(s):
hsa04062; hsa04630; hsa04920; hsa05140
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Tyrosine protein kinase 2
Approved Symbol:
JAK2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 13
Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 21
Human phosphorylation targets: 21; Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE(db);
  • 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile(db);
  • 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide(db);
  • 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM(db);
  • 5-phenyl-1H-indazol-3-amine(db)

    Associated Genetic Diseases:

  • Leukemia, acute myelogenous(Pd);
  • Myeloproliferative disorder with erythrocytosis(Pd);
  • Polycythemia vera(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00993 Entrez Gene ID: 3717 OMIM ID: 147796 Swissprot Accession: O60674;