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Description for Protein IVD

isovaleryl-CoA dehydrogenase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(platelet: 7; undefined: 1)
Summary:
Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.3.99.10
KEGG - Orthology:
K00253
KEGG - Pathway(s):
hsa00280; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ACAD2
Approved Symbol:
IVD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Coenzyme a Persulfide(db);
  • Flavin-Adenine Dinucleotide(db)

    Associated Genetic Diseases:

  • Isovaleric acidemia(Pd);
  • Isovaleric acidemia, type I(Pd);
  • Isovaleric acidemia, type II(Pd);
  • Isovaleric acidemia, type III(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09516 Entrez Gene ID: 3712 OMIM ID: 607036 Swissprot Accession: P26440; B3KVI7;