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Description for Protein ITPR3

inositol 1,4,5-triphosphate receptor, type 3
12 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MIR: Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04960
    KEGG - Pathway(s):
    hsa04020; hsa04070; hsa04114; hsa04270; hsa04540; hsa04720; hsa04730; hsa04742; hsa04912; hsa04970; hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor; IP3 receptor isoform 3; InsP3R3; IP3R3
    Approved Symbol:
    ITPR3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00926 Entrez Gene ID: 3710 OMIM ID: 147267 Swissprot Accession: A6H8K3; Q14573; Q59ES2;