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Description for Protein ITPKB

inositol 1,4,5-trisphosphate 3-kinase B
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.127
KEGG - Orthology:
K00911
KEGG - Pathway(s):
hsa00562; hsa01100; hsa04020; hsa04070
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Inositol 1,4,5-trisphosphate 3-kinase; IP3K; IP3 3-kinase; IP3K-B
Approved Symbol:
ITPKB
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; Platelet phosphorylation sites: 2
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00942 Entrez Gene ID: 3707 OMIM ID: 147522 Swissprot Accession: P27987; B2R9J0;