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Description for Protein ITPKA

inositol 1,4,5-trisphosphate 3-kinase A
6 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.127
KEGG - Orthology:
K00911
KEGG - Pathway(s):
hsa00562; hsa01100; hsa04020; hsa04070
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Inositol 1,4,5-trisphosphate 3-kinase; IP3K; IP3 3-kinase; Inositol 1,4,5-triphosphate 3-kinase A
Approved Symbol:
ITPKA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db);
  • D-Myo-Inositol-1,4,5-Triphosphate(db);
  • Inositol-(1,3,4,5)-Tetrakisphosphate(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00941 Entrez Gene ID: 3706 OMIM ID: 147521 Swissprot Accession: P23677;