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Description for Protein ITK

IL2-inducible T-cell kinase
26 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BTK: Bruton's tyrosine kinase Cys-rich motif
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K07363
    KEGG - Pathway(s):
    hsa04062; hsa04660; hsa04670
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tyrosine-protein kinase LYK; Tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; MGC126257; MGC126258; EC 2.7.10.2; T-cell-specific kinase; Kinase EMT
    Approved Symbol:
    ITK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 9
    Human phosphorylation targets: 8; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Staurosporine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01746 Entrez Gene ID: 3702 OMIM ID: 186973 Swissprot Accession: Q08881;