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Description for Protein ACADVL

acyl-CoA dehydrogenase, very long chain
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 1; microparticles: 1; platelet: 6)
Summary:
The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.3.99.-
    KEGG - Orthology:
    K09479
    KEGG - Pathway(s):
    hsa00071; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    VLCAD; Acyl Coenzyme A dehydrogenase, very long chain; Acyl CoA dehydrogenase, very long chain specific, mitochondrial; LCACD; ACAD6; EC 1.3.99.-; Acyl-Coenzyme A dehydrogenase, very long chain isoform 1 precursor; Acyl-Coenzyme A dehydrogenase, very long chain isoform 2 precursor
    Approved Symbol:
    ACADVL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • VLCAD deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01940 Entrez Gene ID: 37 OMIM ID: 609575 Swissprot Accession: P49748;