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Description for Protein ITIH1

inter-alpha (globulin) inhibitor H1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • VWA: von Willebrand factor (vWF) type A domain
  • VIT: Vault protein Inter-alpha-Trypsin domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Inter alpha trypsin inhibitor, heavy chain 1; IATIH; ITIH; ITI heavy chain H1; Inter alpha trypsin inhibitor complex component III; Serum derived hyaluronan associated protein; SHAP; IGHEP1
    Approved Symbol:
    ITIH1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Inter-alpha-trypsin inhibitor, heavy chain 1 polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00927 Entrez Gene ID: 3697 OMIM ID: 147270 Swissprot Accession: P19827; B7Z558; B7Z8C0;