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Description for Protein EIF6

eukaryotic translation initiation factor 6
49 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(platelet: 5; secretome: 1)
Summary:
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03264
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Integrin beta 4 binding protein of; p27 beta 4 binding protein; p27BBP; EIF6; Eukaryotic translation initiation factor 3A; EIF3A; B4 integrin interactor; CAB; Eukaryotic translation initiation factor 6 isoform a; Eukaryotic translation initiation factor 6 isoform c; b(2)gcn
Approved Symbol:
EIF6
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 15
Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04221 Entrez Gene ID: 3692 OMIM ID: 602912 Swissprot Accession: B7ZBG9; P56537;