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Description for Protein ITGB4

integrin, beta 4
27 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • VWA: von Willebrand factor (vWF) type A domain
  • PSI: domain found in Plexins, Semaphorins and Integrins
  • EGF: Epidermal growth factor-like domain.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06525
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa04810; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Integrin beta 4 isoform 1 precursor; Integrin beta 4 isoform 2 precursor; Integrin beta 4 isoform 3 precursor; Integrin beta-4 subunit; GP150; CD104 antigen
    Approved Symbol:
    ITGB4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 115
    Human (de-) phosphorylation sites: 115; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cacodylate Ion(db)

    Associated Genetic Diseases:

  • Epidermolysis bullosa of hands and feet(Pd);
  • Epidermolysis bullosa with pyloric atresia(Pd);
  • Epidermolysis bullosa, generalized atrophic benign(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00946 Entrez Gene ID: 3691 OMIM ID: 147557 Swissprot Accession: P16144; A0AVL6;