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Description for Protein ITGB3

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
43 total interacting proteins; 35 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/2)
(alpha granules: 1; cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 5; secretome: 1; undefined: 2)
Summary:
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • VWA: von Willebrand factor (vWF) type A domain
  • PSI: domain found in Plexins, Semaphorins and Integrins
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06493
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa04640; hsa04810; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Platelet glycoprotein IIIa; GP3A; Platelet fibrinogen receptor, beta subunit; CD61; HPA-1; HPA-4
    Approved Symbol:
    ITGB3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Antithymocyte globulin(db);
  • Eptifibatide(db);
  • Tirofiban(db)

    Associated Genetic Diseases:

  • CA/TU platelet alloantigen system(Pd);
  • Glanzmann thrombasthenia(Pd);
  • Mo platelet-specific antigen system(Pd);
  • Pen(A)/Pen(B) alloantigen polymorphism(Pd);
  • Pl(A) platelet-specific antigen system(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01428 Entrez Gene ID: 3690 OMIM ID: 173470 Swissprot Accession: P05106;