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Description for Protein ARAF

v-raf murine sarcoma 3611 viral oncogene homolog
31 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RBD: Raf-like Ras-binding domain
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08845
    KEGG - Pathway(s):
    hsa04012; hsa04270; hsa04650; hsa04720; hsa04730; hsa04810; hsa04910; hsa04914; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PKS; PKS2; RAFA1; Oncogene PKS2; Oncogene ARAF1; Proto-oncogene Pks; A-Raf proto-oncogene; Serine/threonine protein kinase Araf1; EC 2.7.1.37
    Approved Symbol:
    ARAF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 50
    Human (de-) phosphorylation sites: 50; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02405 Entrez Gene ID: 369 OMIM ID: 311010 Swissprot Accession: P10398;