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Description for Protein ITGB2

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
40 total interacting proteins; 24 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • VWA: von Willebrand factor (vWF) type A domain
  • PSI: domain found in Plexins, Semaphorins and Integrins
  • EGF: Epidermal growth factor-like domain.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06464
    KEGG - Pathway(s):
    hsa04514; hsa04650; hsa04670; hsa04810; hsa05140; hsa05144; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD18; LFA1; Leukocyte cell adhesion molecule CD18; Complement receptor C3 beta subunit; LAD; MF17; LCAMB; MAC-1; Integrin beta chain, beta 2; Leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; Cell surface adhesion glycoprotein; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD18 antigen
    Approved Symbol:
    ITGB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Simvastatin(db)

    Associated Genetic Diseases:

  • Leukocyte adhesion deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02506 Entrez Gene ID: 3689 OMIM ID: 600065 Swissprot Accession: P05107;