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Description for Protein ITGB1

integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
72 total interacting proteins; 51 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 6)
Summary:
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • VWA: von Willebrand factor (vWF) type A domain
  • PSI: domain found in Plexins, Semaphorins and Integrins
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05719
    KEGG - Pathway(s):
    hsa04360; hsa04510; hsa04512; hsa04514; hsa04670; hsa04810; hsa05100; hsa05130; hsa05131; hsa05140; hsa05200; hsa05222; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Very late activation protein, beta polypeptide; VLA beta; VLAB; CD29; Fibronectin receptor, beta subunit like; FNRBL; MDF2; GPIIA; MSK12; Integrin VLA4 beta subunit; Integrin beta 1 isoform 1C-1; Integrin beta 1 isoform 1A; Integrin beta 1 isoform 1B; Integrin beta 1 isoform 1D; Integrin beta 1 isoform 1C-2; Fibronectin receptor, beta subunit; FNRB
    Approved Symbol:
    ITGB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Antithymocyte globulin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00628 Entrez Gene ID: 3688 OMIM ID: 135630 Swissprot Accession: P05556;