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Description for Protein ITGAX

integrin, alpha X (complement component 3 receptor 4 subunit)
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • VWA: von Willebrand factor (vWF) type A domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06462
    KEGG - Pathway(s):
    hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Leukocyte surface antigen p150,95, alpha subunit; LEU M5, alpha subunit; Myeloid membrane antigen, alpha subunit; CD11C
    Approved Symbol:
    ITGAX
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01051 Entrez Gene ID: 3687 OMIM ID: 151510 Swissprot Accession: P20702; Q8TES5;