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Description for Protein ITGA2B

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
15 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 12/2)
(alpha granules: 1; cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; platelet: 9; secretome: 1; undefined: 1)
Summary:
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06476
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa04640; hsa04810; hsa05200; hsa05222; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Platelet glycoprotein IIB; Alpha 2B integrin; GP2B; Platelet fibrinogen receptor, alpha subunit; Platelet specific antigen BAK; CD41B
    Approved Symbol:
    ITGA2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Tirofiban(db)

    Associated Genetic Diseases:

  • Bak platelet-specific antigen(Pd);
  • Glanzmann thrombasthenia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 06377 Entrez Gene ID: 3674 OMIM ID: 607759 Swissprot Accession: P08514;