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Description for Protein ITGA2

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
13 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/2)
(alpha granules: 1; membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 10; undefined: 1)
Summary:
This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • VWA: von Willebrand factor (vWF) type A domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06481
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa04640; hsa04810; hsa05200; hsa05222; hsa05410; hsa05412; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Very late activation protein 2 receptor, alpha 2 subunit; VLA2 receptor, alpha 2 subunit; VLAA2; CD49B; Platelet glycoprotein Ia/IIa; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA2 alpha chain; CD49b
    Approved Symbol:
    ITGA2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01893 Entrez Gene ID: 3673 OMIM ID: 192974 Swissprot Accession: P17301;