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Description for Protein IRS1

insulin receptor substrate 1
79 total interacting proteins; 58 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • PTBI: Phosphotyrosine-binding domain (IRS1-like)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07187
    KEGG - Pathway(s):
    hsa04722; hsa04910; hsa04920; hsa04930; hsa04960
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Insulin receptor substrate 1
    Approved Symbol:
    IRS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 62
    Human (de-) phosphorylation sites: 62; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID(db)

    Associated Genetic Diseases:

  • Diabetes mellitus, type II(Pd);
  • Insulin resistance, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00943 Entrez Gene ID: 3667 OMIM ID: 147545 Swissprot Accession: P35568;