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Description for Protein IRAK2

interleukin-1 receptor-associated kinase 2
16 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04731
    KEGG - Pathway(s):
    hsa04210; hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IRAK-2; Interleukin 1 receptor-associated kinase 2
    Approved Symbol:
    IRAK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04491 Entrez Gene ID: 3656 OMIM ID: 603304 Swissprot Accession: O43187;