Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein IRAK1

interleukin-1 receptor-associated kinase 1
45 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04730
    KEGG - Pathway(s):
    hsa04210; hsa04620; hsa04722; hsa05140; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IRAK; Pelle; Interleukin 1 receptor associated kinase 1 isoform 1; Interleukin 1 receptor associated kinase 1 isoform 2; Interleukin 1 receptor associated kinase 1 isoform 3; EC 2.7.1.37
    Approved Symbol:
    IRAK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Methyl-2,4-Pentanediol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02235 Entrez Gene ID: 3654 OMIM ID: 300283 Swissprot Accession: P51617; Q96C06;