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Description for Protein PDX1

pancreatic and duodenal homeobox 1
14 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HOX: Homeodomain
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07594
    KEGG - Pathway(s):
    hsa04930; hsa04950
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Homeodomain transcription factor IPF1; Somatostatin transcription factor 1; STF1; PDX1; IDX1
    Approved Symbol:
    PDX1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Diabetes mellitus, type II, susceptibility to(Pd);
  • Maturity-onset diabetes of the young, type IV(Pd);
  • Pancreatic agenesis(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02843 Entrez Gene ID: 3651 OMIM ID: 600733 Swissprot Accession: P52945;