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Description for Protein INSR

insulin receptor
81 total interacting proteins; 50 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Tyr_Kinase: tyrosine kinase domain
  • FU: Furin-like repeats
  • REC: cheY-homologous receiver domain
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K04527
    KEGG - Pathway(s):
    hsa04520; hsa04910; hsa04930; hsa04960
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Insulin receptor isoform Long precursor; Insulin receptor isoform Short precursor; Insulin receptor subunit alpha; Insulin receptor subunit beta; CD220 antigen; IR
    Approved Symbol:
    INSR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 50
    Human (de-) phosphorylation sites: 50; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 33
    Human phosphorylation targets: 19; Predicted platelet targets: 14
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate(db);
  • Insulin Aspart(db);
  • Insulin Detemir(db);
  • Insulin Glargine(db);
  • Insulin Glulisine(db);
  • Insulin Lispro(db);
  • Insulin recombinant(db);
  • Insulin, porcine(db);
  • Mecasermin(db);
  • [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID(db)

    Associated Genetic Diseases:

  • Diabetes mellitus, insulin-resistant(Pd);
  • Diabetes mellitus, insulin-resistant, with acanthosis nigricans(Pd);
  • Diabetes mellitus, noninsulin-dependent(Pd);
  • Hyperinsulinemic hypoglycemia, familial, 5(Pd);
  • Insulin resistance(Pd);
  • Leprechaunism(Pd);
  • Leprechaunism ARK 1, allele 1(Pd);
  • Leprechaunism ARK 1, allele 2(Pd);
  • Leprechaunism minn 1(Pd);
  • Leprechaunism, Atlanta 1 type(Pd);
  • Leprechaunism, Geldeimalsen type(Pd);
  • Leprechaunism, Helmond type(Pd);
  • Leprechaunism, mount sinai type(Pd);
  • Leprechaunism, verona 1 type(Pd);
  • Leprechaunism, Winnipeg type(Pd);
  • Rabson-Mendenhall syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 00975 Entrez Gene ID: 3643 OMIM ID: 147670 Swissprot Accession: P06213;