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Description for Protein INPP5D

inositol polyphosphate-5-phosphatase, 145kDa
33 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 8; undefined: 1)
Summary:
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03084
    KEGG - Pathway(s):
    hsa04070; hsa04662; hsa04664; hsa04666; hsa04910
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    hp51CN; SHIP; Inositol polyphosphate-5-phosphatase, 145kDa; SIP-145; MGC104855; p150Ship; Signaling inositol polyphosphate 5 phosphatase SIP-145; SH2 containing inositol phosphatase isoform b; SH2 containing inositol phosphatase isoform a; SH2 containing inositol phosphatase
    Approved Symbol:
    INPP5D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09033 Entrez Gene ID: 3635 OMIM ID: 601582 Swissprot Accession: Q92835; O00145;