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Description for Protein INPP5B

inositol polyphosphate-5-phosphatase, 75kDa
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4; undefined: 1)
Summary:
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.36
    KEGG - Orthology:
    K01099
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MGC65156; MGC71303; 75 kDa inositol polyphosphate-5-phosphatase; Type II inositol-1,4,5-trisphosphate 5-phosphatase; Inositol polyphosphate-5-phosphatase, 75-KD; 5PTase; EC 3.1.3.36
    Approved Symbol:
    INPP5B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • D-Myo-Inositol-1,4-Bisphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00924 Entrez Gene ID: 3633 OMIM ID: 147264 Swissprot Accession: P32019;