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Description for Protein INS

insulin
18 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04526
    KEGG - Pathway(s):
    hsa04114; hsa04140; hsa04150; hsa04810; hsa04910; hsa04914; hsa04930; hsa04940; hsa04950; hsa04960; hsa05215
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Proinsulin
    Approved Symbol:
    INS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • M-Cresol(db);
  • MYRISTIC ACID(db)

    Associated Genetic Diseases:

  • Hyperproinsulinemia, familial(Pd);
  • Insulin Chicago(Pd);
  • Insulin Wakayama(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01455 Entrez Gene ID: 3630 OMIM ID: 176730 Swissprot Accession: P01308;