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Description for Protein IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CBS: Domain in cystathionine beta-synthase and other proteins.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.1.205
    KEGG - Orthology:
    K00088
    KEGG - Pathway(s):
    hsa00230; hsa00983; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Inosine 5 prime monophosphate dehydrogenase type 2; Inosine 5` monophosphate dehydrogenase 2; IMPD2; EC 1.1.1.205
    Approved Symbol:
    IMPDH2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 6-Chloropurine Riboside, 5'-Monophosphate(db);
  • Ester(db);
  • Inosinic Acid(db);
  • Mycophenolate mofetil(db);
  • Mycophenolic acid(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Ribavirin Monophosphate(db);
  • Selenazole-4-Carboxyamide-Adenine Dinucleotide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00895 Entrez Gene ID: 3615 OMIM ID: 146691 Swissprot Accession: P12268;