Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ILK

integrin-linked kinase
46 total interacting proteins; 34 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 14/1)
(alpha granules: 1; ATP binding: 1; membrane: 2; microparticles: 1; platelet: 11; secretome: 1)
Summary:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K06272
    KEGG - Pathway(s):
    hsa03320; hsa04510; hsa05100; hsa05213
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    59 kDa serine/threonine protein kinase; Integrin linked protein kinase 1; p59ILK; P59; DKFZp686F1765; EC 2.7.1.37
    Approved Symbol:
    ILK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 8
    Human phosphorylation targets: 8; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03842 Entrez Gene ID: 3611 OMIM ID: 602366 Swissprot Accession: Q13418;