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Description for Protein ILF3

interleukin enhancer binding factor 3, 90kDa
25 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • RBD: Raf-like Ras-binding domain
  • DZF: domain in DSRM or ZnF_C2H2 domain containing proteins
  • DSRM: Double-stranded RNA binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13090
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MMP4; DRBF; NF-AT-90; TCP80; dsRNA binding protein NFAR-2/MPP4; Translational control protein 80; Interleukin enhancer binding factor 3, 90kDa; Interleukin enhancer binding factor 3 isoform b; Interleukin enhancer binding factor 3 isoform a; Interleukin enhancer binding factor 3 isoform c; Nuclear factor of activated T cells, 90kD; NF90; Double-stranded-RNA (dsRNA) binding proteins, 76-KD; Nuclear factor associated with dsRNA; NFAR; M-phase phosphoprotein 4; MPP4; MPHOSPH4; NFAR-1; DRBP76
    Approved Symbol:
    ILF3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 76
    Human (de-) phosphorylation sites: 76; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04420 Entrez Gene ID: 3609 OMIM ID: 603182 Swissprot Accession: Q12906;