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Description for Protein IL12B

interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • IGC2: Immunoglobulin C-2 Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05425
    KEGG - Pathway(s):
    hsa04060; hsa04620; hsa04622; hsa04630; hsa04940; hsa05140; hsa05142; hsa05330
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; Interleukin 12 beta chain; NK cell stimulatory factor chain 2; NKSF2; IL12 subunit p40; IL23 subunit p40; Cytotoxic lymphocyte maturation factor 2; CLMF2; Natural killer cell stimulatory factor, 40 kDa subunit; CTL maturation factor; TCMF; T-cell stimulating factor; TSF
    Approved Symbol:
    IL12B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-Mercapto-2-Nitro-Benzoic Acid(db);
  • Alpha-D-Mannose(db)

    Associated Genetic Diseases:

  • Asthma, severe, susceptibility to(Pd);
  • Bcg and salmonella infection, disseminated(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01194 Entrez Gene ID: 3593 OMIM ID: 161561 Swissprot Accession: P29460;