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Description for Protein IL12A

interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
6 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K05406
KEGG - Pathway(s):
hsa04060; hsa04620; hsa04622; hsa04630; hsa04940; hsa05140; hsa05142; hsa05144; hsa05330
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
IL12 subunit p35; Cytotoxic lymphocyte maturation factor; CLMF; Natural killer cell stimulatory factor, 35 kDa subunit; NKSF1; IL-12A; CLMF p35; NK cell stimulatory factor chain 1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; Interleukin 12 alpha chain; TCMF; CTL maturation factor; T-cell stimulating factor; TSF
Approved Symbol:
IL12A
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01193 Entrez Gene ID: 3592 OMIM ID: 161560 Swissprot Accession: P29459; O60595;