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Description for Protein AQP1

aquaporin 1 (Colton blood group)
10 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09864
    KEGG - Pathway(s):
    hsa04964
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CHIP28; AQP CHIP; Aquaporin CHIP; Urine water channel; Channel like integral membrane protein, 28-KD; Water channel protein for red blood cells and kidney proximal tubule; Colton blood group; Aquaporin-1 (channel-forming integral protein, 28kDa)
    Approved Symbol:
    AQP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acetazolamide(db);
  • B-Nonylglucoside(db)

    Associated Genetic Diseases:

  • Aquaporin 1 deficiency(Pd);
  • Colton blood group polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 00140 Entrez Gene ID: 358 OMIM ID: 107776 Swissprot Accession: P29972;