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Description for Protein IL8

interleukin 8
23 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SCY: Intercrine alpha family (small cytokine C-X-C) (chemokine CXC).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10030
    KEGG - Pathway(s):
    hsa04060; hsa04062; hsa04620; hsa04621; hsa04622; hsa05120; hsa05131; hsa05142; hsa05144; hsa05200; hsa05219
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IL-8; Small inducible cytokine subfamily B, member 8; SCYB8; Monocyte derived neutrophil chemotactic factor; Monocyte derived neutrophil activating protein; MDNCF; Neutrophil activating peptide 1; NAP1; GCP1; Granulocyte chemotactic protein 1; CXC chemokine ligand 8; CXCL8; T-cell chemotactic factor; Lymphocyte derived neutrophil activating factor; LYNAP; Protein 3-10C; Neutrophil activating factor; NAF; Emoctakin; LECT; LUCT; TSG-1; MONAP; AMCF-I; b-ENAP K60
    Approved Symbol:
    IL8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00909 Entrez Gene ID: 3576 OMIM ID: 146930 Swissprot Accession: P10145;