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Description for Protein IL6ST

interleukin 6 signal transducer (gp130, oncostatin M receptor)
32 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; phosphoproteome: 1; undefined: 1)
Summary:
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05060
    KEGG - Pathway(s):
    hsa04060; hsa04630
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GP130 transducer chain; Interleukin 6 signal transducer; IL 6R beta; Membrane glycoprotein 130; GP130; Oncostatin M receptor; CDw130; CD130 antigen; CD130; GP130-RAPS; Gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; Interleukin receptor beta chain; Membrane glycoprotein gp130; Interleukin 6 signal transducer isoform 2; Interleukin 6 signal transducer isoform 1 precursor
    Approved Symbol:
    IL6ST
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02824 Entrez Gene ID: 3572 OMIM ID: 600694 Swissprot Accession: P40189;