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Description for Protein IL6R

interleukin 6 receptor
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • IGC2: Immunoglobulin C-2 Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05055
    KEGG - Pathway(s):
    hsa04060; hsa04630; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Interleukin 6 receptor isoform 2; Interleukin 6 receptor isoform 1 precursor; CD126; IL6RA; Interleukin 6 receptor; IL-6R-1; IL-6R-alpha; CD126 antigen; MGC104991; IL-6 sR
    Approved Symbol:
    IL6R
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01000 Entrez Gene ID: 3570 OMIM ID: 147880 Swissprot Accession: P08887; A0N0L5;