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Description for Protein IL5RA

interleukin 5 receptor, alpha
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05067
    KEGG - Pathway(s):
    hsa04060; hsa04630; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CDw125; HSIL5R3; MGC26560; Interleukin 5 receptor, alpha isoform 1 precursor; Interleukin 5 receptor, alpha isoform 2 precursor; Interleukin 5 receptor, alpha isoform 3 precursor; IL 5R alpha; IL5R; Interleukin 5 receptor alpha chain; CD125 antigen; Interleukin 5 receptor, type 3
    Approved Symbol:
    IL5RA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 1
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00998 Entrez Gene ID: 3568 OMIM ID: 147851 Swissprot Accession: Q14632; Q8NHV7; Q01344;