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Description for Protein IL4

interleukin 4
6 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05430
    KEGG - Pathway(s):
    hsa04060; hsa04630; hsa04640; hsa04660; hsa04664; hsa04672; hsa05140; hsa05310; hsa05320; hsa05330
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Interleukin 4 isoform 2 precursor; Interleukin 4 isoform 1 precursor; BSF1; B cell stimulatory factor 1; Lymphocyte stimulatory factor 1; B cell growth factor; BCGF; B cell differentiation factor gamma; BCDF gamma; IL-4; MGC79402
    Approved Symbol:
    IL4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00989 Entrez Gene ID: 3565 OMIM ID: 147780 Swissprot Accession: P05112; Q5FC01;