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Description for Protein IL3

interleukin 3 (colony-stimulating factor, multiple)
7 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04736
    KEGG - Pathway(s):
    hsa04060; hsa04210; hsa04630; hsa04640; hsa04664; hsa05310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Multi CSF; Multipotential colony stimulating factor; Hematopoietic growth factor; Mast cell growth factor; MCGF; P cell stimulating factor
    Approved Symbol:
    IL3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amlexanox(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00987 Entrez Gene ID: 3562 OMIM ID: 147740 Swissprot Accession: P08700;