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Description for Protein FASLG

Fas ligand (TNF superfamily, member 6)
42 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TNF: Tumour necrosis factor family.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04389
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04210; hsa04650; hsa04722; hsa04940; hsa05142; hsa05200; hsa05320; hsa05330; hsa05332
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FS-7 and FL associated cell surface antigen; Tumor necrosis factor ligand superfamily, member 6; TNFSF6; FASL; Apoptosis antigen ligand 1; APT1LG1; CD95 ligand; CD95L; CD178; FAS; Apoptosis (APO 1) antigen ligand 1
    Approved Symbol:
    FASLG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Autoimmune lymphoproliferative syndrome, type Ib(Pd);
  • Lung cancer, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00610 Entrez Gene ID: 356 OMIM ID: 134638 Swissprot Accession: P48023; Q53ZZ1;