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Description for Protein IL2RA

interleukin 2 receptor, alpha
9 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SUSHI: Sushi domain (SCR repeat)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05068
    KEGG - Pathway(s):
    hsa04060; hsa04144; hsa04630; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TAC antigen; IL2 receptor; IL2R; IL2R, alpha chain; T cell growth factor receptor; TCGFR; CD25; IL2 receptor alpha subunit; P55; CD25 antigen
    Approved Symbol:
    IL2RA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Aldesleukin(db);
  • Basiliximab(db);
  • Daclizumab(db);
  • Denileukin diftitox(db)

    Associated Genetic Diseases:

  • Interleukin 2 receptor, alpha, deficiency of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00986 Entrez Gene ID: 3559 OMIM ID: 147730 Swissprot Accession: P01589;