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Description for Protein IL1RN

interleukin 1 receptor antagonist
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IL1: Interleukin-1 homologues
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05481
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Interleukin 1 receptor antagonist isoform 2; Interleukin 1 receptor antagonist isoform 1 precursor; Interleukin 1 receptor antagonist isoform 3; Interleukin 1 receptor antagonist isoform 4; IL1RA; IL 1RA; ICIL 1RA; IRAP; IL 1RN; IL-1ra3; IL1F3; MGC10430; Intracellular IL-1 receptor antagonist type II; Intracellular interleukin-1 receptor antagonist; Type II interleukin-1 receptor antagonist; Interleukin-1 receptor antagonist protein; IL1 inhibitor
    Approved Symbol:
    IL1RN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Gastric cancer risk after H. pylori infection(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00978 Entrez Gene ID: 3557 OMIM ID: 147679 Swissprot Accession: Q53SC2; P18510;