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Description for Protein IL1B

interleukin 1, beta
13 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IL1: Interleukin-1 homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04519
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04210; hsa04620; hsa04621; hsa04623; hsa04640; hsa04940; hsa05010; hsa05020; hsa05140; hsa05142; hsa05144; hsa05332
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IL1 beta; Catabolin; IL1F2
    Approved Symbol:
    IL1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Canakinumab(db);
  • Gallium nitrate(db);
  • Minocycline(db)

    Associated Genetic Diseases:

  • Gastric cancer risk after H. pylori infection(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00985 Entrez Gene ID: 3553 OMIM ID: 147720 Swissprot Accession: P01584;